progeny本身有自己的R包，可以提取通路基因集信息，团队把他嵌入另一个R包decoupleR中完成富集分析。decoupleR自己有详细的针对bulk和scRNAseq的教程
简单安装一下
devtools::install_github('saezlab/OmnipathR')
devtools::install_github("saezlab/progeny")
BiocManager::install("saezlab/decoupleR")Inside PROGENy, one can find gene signatures for 14 different pathways:
- Androgen: involved in the growth and development of the male reproductive organs.
- EGFR: regulates growth, survival, migration, apoptosis, proliferation, and differentiation in mammalian cells
- Estrogen: promotes the growth and development of the female reproductive organs.
- Hypoxia: promotes angiogenesis and metabolic reprogramming when O2 levels are low.
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